In this article, Manchak proves how little local observers can know about the global structure of spacetime in the context of general relativity. In particular, he shows that, for almost any cosmological model, no amount of local data could ever single it out as the unique model accurately describing our universe. Even if one assumes a principle of uniformity of physical laws, major epistemological issues still remain. In a certain sense, our cosmological models are therefore completely underdetermined, even when the background theory of gravity is specified in advance.